At the time of European contact, the Cherokee inhabited a region consisting of what is now western North Carolina and parts of Virginia, Georgia, and eastern Tennessee. Over the next two centuries, the tribe expanded through the southern Appalachians, reaching further into Georgia as well as into South Carolina, northeastern Alabama, and across the Cumberland River into Kentucky and West Virginia; some of this expansion occurred following the displacement of other tribes.
By the 1780s, Cherokee migration into Arkansas had begun, largely in response to pressure to move away from Euro-American settlements in the East following the Revolutionary War.