Indigenous peoples in what is now the contiguous United States are commonly called "American Indians", or just "Indians" domestically, but are also often referred to as "Native Americans". In Alaska, indigenous peoples, which include Native Americans, Yupik and Inupiat Eskimos, and Aleuts, are referred to collectively as Alaska Natives.

Native Americans and Alaska Natives make up 2 percent of the population, with more than 6 million people identifying themselves as such, although only 1.8 million are recognized as registered tribal members. Tribes have established their own rules for membership, some of which are increasingly exclusive. More people have unrecognized Native American ancestry together with other ethnic groups.

A minority of U.S. Native Americans live in land units called Indian reservations. Some southwestern U.S. tribes, such as the Yaqui and Apache, have registered tribal communities in Northern Mexico. Similarly, some northern bands of Blackfoot reside in southern Alberta, Canada, in addition to within US borders.

A number of Kumeyaay communities may be found in Baja California del Norte.